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Supadopa TR 36.25mg+145mg Capsule
- Supadopa TR 145 is prescribed to help manage Parkinson’s disease symptoms.
- It can be taken with or without food, as directed by your doctor.
- Avoid high-protein foods like meat, poultry, and dairy, as they may reduce drug absorption.
- When starting the medication, stand up slowly from sitting or lying down to prevent dizziness or fainting.
- Please do not stop taking the medication suddenly without consulting your doctor, as it may cause severe withdrawal symptoms like fever, muscle stiffness, abnormal movements, sweating, and confusion.
- Inform your doctor if you experience hallucinations or behavioral changes.
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✅ Description:
Supadopa TR 145 is a combination medication used to manage Parkinson’s disease. It effectively relieves symptoms such as tremors, muscle stiffness, and difficulty with movement. It can be taken without food, but high-protein meals and dairy products should be avoided, as they may interfere with absorption. To maintain stable drug levels in the body, it is recommended to take the medication simultaneously each day.
Always follow your doctor's prescribed dose and duration. If you miss a dose, take it as soon as you remember, but never skip doses or discontinue treatment without medical advice, as stopping suddenly may cause adverse effects. Common side effects include nausea, vomiting, dry mouth, constipation, headache, dizziness, and drowsiness. Initially, the medication may cause a sudden drop in blood pressure upon standing, so rise slowly if you’ve been sitting or lying down. Since it can cause dizziness and drowsiness, avoid driving or engaging in activities that require focus until you know how it affects you.
If you have liver or kidney disease, consult your doctor before taking this medication. Additionally, inform your doctor about any other medications you are using, as some may interfere with the effectiveness of Supadopa TR 145. Pregnant and breastfeeding women should seek medical advice before using this medication.
Safety Advices
Alcohol
UNSAFE
Avoid consuming alcohol while taking Supadopa TR 145, as it may increase the risk of side effects like dizziness and drowsiness.
Pregnancy
CONSULT YOUR DOCTOR
Limited human studies are available, but animal research suggests potential harm to the developing baby. Your doctor will assess the risks and benefits before prescribing.
Breastfeeding
While limited human data suggests no significant risk to the baby, the medication may partially or completely suppress lactation. Normal lactation resumes once the treatment is stopped.
Driving
Be cautious when driving or performing tasks requiring concentration, as the medication may cause drowsiness.
Kidney
Available data suggests that dose adjustment may not be required in patients with kidney disease. However, consulting a doctor is recommended.
Liver
Supadopa TR 145 should be used with caution in patients with liver disease. A dose adjustment may be necessary. Consult your doctor for guidance.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses of Supadopa TR 36.25mg+145mg Capsule
Treatment of Parkinson’s disease
✔️ Mechanism of Action
- Levodopa is a precursor to dopamine. It crosses the blood-brain barrier and is converted into dopamine within the brain to help manage movement disorders.
- Carbidopa prevents the premature breakdown of levodopa in the peripheral tissues, increasing the amount of levodopa that reaches the brain for dopamine production.
✔️ Side Effects of Supadopa TR 36.25mg+145mg Capsule
- Nausea
- Vomiting
- Dry mouth
- Constipation
- Dizziness
- Drowsiness
- Headache
- Abnormal dreams
- Anxiety
- Insomnia (difficulty sleeping)
- Uncontrolled body movements
- Orthostatic hypotension (sudden drop in blood pressure upon standing)
✔️ Supadopa TR 145 contains two active ingredients:
- Levodopa is a precursor to dopamine converted in the brain to help regulate movement.
- Carbidopa – A decarboxylase inhibitor that prevents levodopa from breaking down outside the brain, allowing more of it to reach the brain and increase dopamine levels.
✔️ Dosage Guidelines for Supadopa TR 145 Adult Dosage
For Parkinson’s Disease & Parkinson-Like Disorders:
Immediate-Release Formulation:
- Initial dose: 25 mg/100 mg every 8 hours or 10 mg/100 mg every 6–8 hours
- Levodopa dosage may be increased by 100 mg per day every 1–2 days
- Carbidopa intake should be within 70–100 mg per day, not exceeding 200 mg per day
- Levodopa should not exceed 800 mg per day
Controlled-Release (CR) Tablet:
- Initial dose: 50 mg/200 mg every 12 hours
- Maximum levodopa dose: 1,600 mg per day
- Doses should be spaced at least 6 hours apart
For Hepatic Impairment:
- Safety and effectiveness have not been well established; use with caution
Pediatric Dosage
- Safety and efficacy in children have not been established
Renal Dosage Adjustments
- For Renal Impairment:
- Safety and effectiveness have not been well established; use with caution
✔️ Supadopa TR 145 should not be used in individuals with:
- Lactation (breastfeeding)
- Narrow-angle glaucoma
- Melanoma
- Psychosis
- Severely decompensated endocrine disorders
✔️ Directions for Use: Supadopa TR 36.25mg+145mg Capsule
Take this medication as prescribed by your doctor. Swallow the capsule whole—do not chew, crush, or break it. It should be taken on an empty stomach. Avoid high-protein foods such as cheese, eggs, milk, and protein powders, as they may reduce the drug’s absorption.
✔️ Drug Interactions
- Decreased Effectiveness of Levodopa: Pyridoxine (Vitamin B6) reverses the effects of levodopa.
- Synergistic Effects: Type-B MAO inhibitors enhance the effects of levodopa.
- Reduced Effectiveness Due to Other Medications: Phenothiazines, haloperidol, reserpine, pyridoxine, diazepam, oxazepam, chlordiazepoxide, and phenobarbital.
- Enhanced Effects of Levodopa: Carbidopa, amantadine, anticholinergics, and amphetamines.
- Enhanced Effects of Sympathomimetic Agents.
- Potentially Fatal Interactions:
- Severe hypotension with bethanidine, bretylium, and guanethidine.
- Hypertensive crisis with furazolidone or monoamine oxidase (MAO) inhibitors.
✔️ Pregnancy & Lactation
- Pregnancy Category C: Use only if the potential benefits justify the risks.
- Lactation: This medication may reduce milk production; use with caution.
✔️ Storage:
Store at a temperature not exceeding 30°C in a dry place. Protect from moisture.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
